Role of Distinct NMDA Receptor Subtypes at Central Synapses

By S. Cull-Candy, Daniel N. Leszkiewicz. Science's STKE, 2004

839 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/155984666bc1aad9c2d5290a6e48537978d47a58

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Molecular Biology

Citations in the corpus

Regulation of NMDA Receptor Subunit Expression and Its Implications for LTD, LTP, and Metaplasticity (2008, background): “Readers are directed to other recent reviews for a more in-depth perspective on the functions and regulation of NMDARs (Cull-Candy and Leszkiewicz, 2004; Kopp et al., 2007; Lau and Zukin, 2007) and for additional hypotheses regarding the induction of metaplasticity (Abraham, 2008).”
NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo (2007, background): “The two receptor subpopulations mediate calcium influx with distinct kinetics (Cull-Candy and Leszkiewicz, 2004); therefore, selective activation of one or the other may provide differentially required levels and kinetics of rising [Ca 2 ]i in the postsynaptic neurons (Choi, 1994; Lipton and Nicoter”
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. (2007, positive): “One of the key mediators of plasticity is the N-methyl-Dasparate (NMDA) type of glutamate receptors, which are composed of subunit families of NMDA receptors (NMDARs) NR1 and NR2 (Cull-Candy and Leszkiewicz, 2004).”
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders (2007, background): “NMDARs are heteromeric assemblies of NR1 , NR2 and NR3 subunits, which co-translationally assemble in the endoplasmic reticulum (ER) to form functional channels with differing physiological and pharmacological properties and distinct patterns of synaptic targetin”
Astrocyte control of synaptic transmission and neurovascular coupling. (2006, background): “Can this activation of extrasynaptic NR2B-NMDARs hint at a distinct role of this astrocyte-to-neuron signaling? There is increasing awareness that synaptic and extrasynaptic NMDARs may subserve different, and to some extent opposing, functional roles (42, 213).”
Glutamate exocytosis from astrocytes controls synaptic strength (2007, background): “which indicated that synaptic NMDARs in granule cells contain NR2A or, possibly, NR2A-NR2B combinations, poorly inhibited by ifenprodi”
NMDA receptor subunits: function and pharmacology. (2007, background): “Triheteromeric NMDARs complicate native NMDAR pharmacology There is compelling evidence that NMDARs are not always simple binary assemblies of NR1 with only one type of NR2 subunit, and that some receptors can incorporate two types of NR2 subunits [1,2].”