Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.

By S. Sigismund, E. Argenzio, D. Tosoni, E. Cavallaro, Simona Polo, P. P. Di Fiore. Developmental Cell, 2008

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Emerging functions of the EGFR in cancer (2017, background): “In addition, through recycling, CME also serves to prolong EGFR signaling, a requirement critical to achieve a productive proliferative response, and to polarize EGFR signaling to specific regions of the PM (Bisi et al., 2013; Sigismund et al., 2012).”
Molecular mechanism and physiological functions of clathrin-mediated endocytosis (2011, background): “Moreover, under conditions of low ligand concentrations of some RTKs, such as EGFR, clathrin-mediated endocytosis directs the receptors to the endosomal recycling pathway, which allows sustained signalling by trafficking the receptors back to the cell surfac”
Feedback regulation of EGFR signalling: decision making by early and delayed loops (2011, background): “Yet another study suggested that the clathrin-mediated route prolongs EGF signalling through EGFR recycling, but at high ligand concentrations clathrin-independent pathways that terminate signalling are favoure”