TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

By N. Bhowmick, A. Chytil, David Plieth, Agnieszka E. Gorska, N. Dumont, S. Shappell, M. Washington, Eric G. Neilson, H. Moses. Science, 2004

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Friends or foes — bipolar effects of the tumour stroma in cancer (2004, background): “On the one hand, inhibition of TGFβ signalling in stromal fibroblasts by blockade of TGFβ receptor II was shown to induce progression to malignancy in epithelial cell”
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. (2009, background): “Alterations in the stroma can promote epithelial tumorigenesis (Barcellos-Hoff and Ravani, 2000; Bhowmick et al., 2004; Maffini et al., 2004).”
TGFβ in Cancer (2008, background): “Building on this observation, Bhowmick et al. (2004) generated mice with a targeted deletion of TGFBRII in fibroblasts.”
Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer (2006, neutral): “Recent results that highlight the role of stromal–epithelial crosstalk in the regulation of cancer have shown that stromal fibroblast TGFβ signal transduction can be important for the suppression of tumorigenesis in the adjacent epitheliu”