Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
By H. Maeda, J. Wu, T. Sawa, Y. Matsumura, K. Hori. Journal of Controlled Release, 2000
6,027 citations recorded by the source corpus.
Subfields: Cancer Research, Oncology
View Paper: https://www.semanticscholar.org/paper/c246bfc0c8075b10fd69337a9118f314306471fa
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Xiaoyuan Chen
- Yongqian Shu
- Peter L. Choyke
- Sanjiv Sam Gambhir
- Ke Wei
- Xinming Jing
- Hisataka Kobayashi
- Jun Wu
In Oncology
- N. Desai
- Elif S. Seven
- Zhili Peng
- Peter L. Choyke
- S. Sahoo
- Jerry S H Lee
- Hisataka Kobayashi
- G. Shapiro
Citations in the corpus
- Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release (2010, background): “the tumors by the enhanced permeability and retention (EPR) effect, leading to a higher drug concentration at the tumor site and decreased toxicity compared with systemic administration (7).”
- The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application (2021, background): “This deficiency results in the retention of extravasated macromolecules in tumor tissues, which provides the opportunity for passive targeting delivery of macromolecular anticancer drugs [1,7,22].”
- Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging (2009, background): “Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.”
- Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “However, such newly formed blood vessels are leaky because of their discontinuous endothelium, along with the obstruction of lymphatic drainage, producing vascular hyperpermeability and enhanced permeation [41].”
- A Brain Tumor Molecular Imaging Strategy Using A New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle (2012, positive): “As the MPR approach relies on the EPR effect, it could potentially be applied to image other cancer types with intrinsic EPR effect including: lung cancer, melanoma, renal cancer, hepatoma, and many others 35 .”