Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.
By Alessandro Senes, Mark Gerstein, Donald M. Engelman. Journal of Molecular Biology, 2000
614 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c22ed7206f60b1bf1c4213cc17e1f3df11eb5609
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In Molecular Biology
Citations in the corpus
- Comparison of Helix Interactions in Membrane and Soluble α-Bundle Proteins (2002, background): “The second motif that appears to be common in helix-tohelix association in membrane proteins is exemplified by the GxxxG motif observed in glycophorin A. The GxxxG sequence was the most dominant motif found in a statistical analysis of membrane protein sequences ( Senes et al., 2000 ) and dimerizati”
- De novo protein design, a retrospective (2020, background): “…such as the GX3G, found in glycophorin A. GX3G, or more generally the Small-X3-Small (in which Small is Gly, Ala, or Ser) motif is involved in both intramolecular folding as well as intermolecular assembly of TM helices (Langosch et al., 1996; Brosig and Langosch, 1998; Senes et al., 2000, 2001).”
- Computational design of a protein crystal (2012, background): “At this interface, the design yields a parallel GX3G motif, often observed at interhelical contacts (45, 46, 50, 51).”
- Serine and Threonine Residues Bend α-Helices in the χ1 = g− Conformation (2000, background): “Moreover, statistical analysis of transmembrane sequences has shown that the most frequent amino acids are Leu Ile Val Ala Phe Gly Ser Thr (Senes et al., 2000).”
- Ser and Thr Residues Modulate the Conformation of Pro-Kinked Transmembrane α-Helices (2004, methodology): “To find overrepresented and underrepresented patterns we calculated the expected number of occurrences with the TMSTAT formalism that accounts for both the relative frequency of the amino acids and length of the sequence (Senes et al., 2000) (see http:// bioinfo.mbb.yale.edu/tmstat/).”