The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus

By Francis Alonzo, Victor J. Torres. 2014

266 citations recorded by the source corpus.

Subfields: Infectious Diseases, Public Health, Environmental and Occupational Health

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Victor J. Torres
2. M. Otto
3. Francis Alonzo
4. Justin S. Bae
5. Gordon Y C Cheung
6. Ashira Lubkin
7. Ashley L. DuMont
8. David B. A. James

In Public Health, Environmental and Occupational Health

1. Gordon Y C Cheung
2. M. Otto
3. Justin S. Bae
4. Victor J. Torres
5. Ashley L. DuMont
6. Francis Alonzo

Citations in the corpus

• Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus (2019, background): “The bicomponent leukocidins are composed of two subunits, a receptor targeting S-type subunit (for “slow” migration in chromatography columns: LukS-PV, LukE, HlgA, HlgC, and LukA) and a polymerizing F-type subunit (for “fast” migration in chromatography columns: LukF-PV, LukD, HlgB, and LukB) (8, 9)”
• Exploiting dominant‐negative toxins to combat Staphylococcus aureus pathogenesis (2016, unknown): “These toxins are secreted as two water-soluble monomers (named S (slow)- or F (fast)- subunit, based on their elution profiles in liquid chromatography) [4].”
• Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular (2015, background): “aureus produces many different virulence factors including several cytotoxic beta-barrel pore-forming toxins such as: α-toxin (Hla), Leukocidin AB (LukAB), Leukocidin ED (LukED), Panton-Valentine leukocidin (PVL), and gamma hemolysins (HlgAB and HlgCB) [2,3].”
• Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5 (2016, unknown): “Six leukocidins have been identified in S. aureus: LukED, LukSF-PV (or Panton-Valentine leukocidin [PVL]), HlgAB, HlgCB, LukAB, and LukMF= (39).”
• Pathogenicity and virulence of Staphylococcus aureus (2021, methodology): “capable of producing at least three (γ-toxin and LukAB/ GH) leukocidins [141].”
• Staphylococcus aureus Impairs the Function of and Kills Human Dendritic Cells via the LukAB Toxin (2019, unknown): “These toxins target a wide array of immune cells (9, 10), the most extensively studied of which are the neutrophils, representing critical components of the initial immune defense against bacteria (7).”