Protein-lipid interplay in fusion and fission of biological membranes.

By L. Chernomordik, Michael M. Kozlov. Annual Review of Biochemistry, 2003

779 citations recorded by the source corpus.

Disparate biological processes involve fusion of two membranes into one and fission of one membrane into two. To formulate the possible job description for the proteins that mediate remodeling of biological membranes, we analyze the energy price of disruption and bending of membrane lipid bilayers at the different stages of bilayer fusion. The phenomenology and the pathways of the well-characterized reactions of biological remodeling, such as fusion mediated by influenza hemagglutinin, are compared with those studied for protein-free bilayers. We briefly consider some proteins involved in fusion and fission, and the dependence of remodeling on the lipid composition of the membranes. The specific hypothetical mechanisms by which the proteins can lower the energy price of the bilayer rearrangement are discussed in light of the experimental data and the requirements imposed by the elastic properties of the bilayer.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c20d71cbbdd1464150cc5777e293229b628bb6d6

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Citations in the corpus

Membrane curvature at a glance (2015, background): “…phosphates (PtdIns) confers an inverted conical shape to the lipids, thereby favoring the bending of the membrane into a positive curvature, bending the monolayer away from the headgroups (reviewed in Chernomordik and Kozlov, 2003; Di Paolo and De Camilli, 2006; Zimmerberg and Kozlov, 2006).”
Mechanics of membrane fusion (2008, background): “Investigations of the fusion pathways for protein-free lipid membranes have identified and characterized two important types of intermediates: hemifusion structures and fusion pores (reviewed in refs”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “It is possible that the fusion of liposomes with the plasma membrane may occur via bilayer fusion intermediates, namely by hemifusion structures and fusion pores (Lentz et al., 2000; Chernomordik and Kozlov, 2003; 2008).”
Mechanisms of membrane fusion: disparate players and common principles (2008, background): “It is now believed that most, if not all, biological membrane fusion proceeds through a hemifusion intermediat”
The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. (2014, background): “Elastic membrane deformation, such as curvature elasticity, depends on the energies of lipid tilt and splay, which in turn are dependent on lipid composition [70,71].”
Viral membrane fusion (2008, neutral): “Fusion of two bilayer membranes is thermodynamically favorable, but there is a very high kinetic barrie”
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, neutral): “The possible functioning of Nox complexes within these or other intracellular membranous structures warrants further investigation.”