Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.

By Scott A. Irwin, B. Patel, Madhuri Idupulapati, J. Harris, Ralph A. Crisostomo, Brian P Larsen, F. Kooy, P. Willems, P. Cras, P. Kozlowski and 3 more. American journal of medical genetics, 2001

764 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c18a7e94b17aa3fae7e082e77e08e98cd0e03b03

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In Genetics

1. Hong Zhang
2. E. Chen
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Citations in the corpus

• Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. (2010, positive): “We hypothesized that such FMRPassociated miRNAs might regulate synaptic function and dendritic spine structure, given the well-established synaptic abnormalities found in FMR1 knockout (KO) mice that are also central to the pathogenesis of FXS in humans (Comery et al., 1997; Irwin et al., 2001).”
• Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “FMRP is mutated in Fragile X Syndrome, a human syndrome associated with mental retardation, indicating that spatial regulation of local mRNA translation is crucial to proper functioning of neuronal circuits (Irwin et al., 2001; Nimchinsky et al., 2001).”
• A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. (2002, background): “Pathology in the brains of fragile X patients and Fmr1 knockout mice show the presence of abnormal dendritic spines reminiscent of a maturation delay (Greenough et al. 2001; Irwin et al. 2001).”
• Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. (2010, methodology): “…et al., 1999; Dietzmann and von Bossanyi, 1994; Ferrer and Galofre, 1987; Fiala et al., 2002; Garey et al., 1998; Huttenlocher and Dabholkar, 1997; Irwin et al., 2000, 2001; Jacobs et al., 1997, 2001; Michel and Garey, 1984; Multani et al., 1994; Suetsugu and Mehraein, 1980; Swann et al., 2000).”
• Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb (2011, background): “largely confirmed the spine phenotype observed in the neocortex of FXS patients (Rudelli et al., 1985; Hinton et al., 1991; Wisniewski et al., 1991; Irwin et al., 2001), with an increased density of longer spines in adult neocortical neurons (Comery et al.”
• Fragile X Mental Retardation Protein: A Paradigm for Translational Control by RNA-Binding Proteins (2015, background): “The absence of FMRP in the neurons leads to subtle developmental abnormalities in the brain such as neurons having immature, thin and highly branched dendritic spines (Irwin et al., 2001).”
• The role of the Rho GTPases in neuronal development. (2005, background): “Indeed, abnormal dendritic spines have been observed in FRAXA patients, where spines are thin, elongated, and have small synaptic contacts typical of immature spines (Hinton et al. 1991; Irwin et al. 2001); in FMR1 knockout mice (Comery et al.”