Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake.
By C. Walkey, Jonathan B. Olsen, Hongbo Guo, Andrew Emili, W. Chan. Journal of the American Chemical Society, 2012
1,789 citations recorded by the source corpus.
Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/bd98d5e5d01c391fec8223f90adde4426943e5e2
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In Biomaterials
In Electronic, Optical and Magnetic Materials
In Materials Chemistry
Citations in the corpus
- PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, neutral): “Of note, NPs can also be directly captured by macrophages by opsonin-independent scavenger receptors [18-20] that often recognize repeating patterns [12].”
- Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. (2016, background): “Nanoparticles with highly cationic and anionic surface charges adsorb a significant amount of serum proteins to form a ‘protein corona’, may aggregate, and display an increased interaction with macrophages in vitro [20].”
- Engineered nanoparticles interacting with cells: size matters (2014, background): “1 ICP-AES No significant size dependency [52]”
- Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. (2014, methodology): “abundance in serum because low abundance proteins are selectively enriched on the nanoparticle surface.(32,33,49) 51 To provide functional information, identified proteins”
- Control of Polymeric Nanoparticle Size to Improve Therapeutic Delivery (2015, background): “However, even at high PEG density not all NP protein absorption is prevented [59].”
- Endocytosis and exocytosis of nanoparticles in mammalian cells (2014, background): “In addition, the uptake efficiency of PEGylated nanoparticles is closely related to PEG grafting density, which can determine the protein absorption.(17) That is, high PEG-grafting density inhibits protein adsorption on the nanoparticle surface in the biological solution.”
- Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases. (2016, background): “Over 70 different serum proteins have been reported to adsorb to the surface of gold NPs [66].”