FlyBase 2.0: the next generation
By Jim Thurmond, J. Goodman, V. Strelets, H. Attrill, L. Gramates, Steven J. Marygold, B. Matthews, G. Millburn, Giulia Antonazzo, V. Trovisco and 24 more. Nucleic Acids Res., 2018
673 citations recorded by the source corpus.
Abstract FlyBase (flybase.org) is a knowledge base that supports the community of researchers that use the fruit fly, Drosophila melanogaster, as a model organism. The FlyBase team curates and organizes a diverse array of genetic, molecular, genomic, and developmental information about Drosophila. At the beginning of 2018, ‘FlyBase 2.0’ was released with a significantly improved user interface and new tools. Among these important changes are a new organization of search results into interactive lists or tables (hitlists), enhanced reference lists, and new protein domain graphics. An important new data class called ‘experimental tools’ consolidates information on useful fly strains and other resources related to a specific gene, which significantly enhances the ability of the Drosophila researcher to design and carry out experiments. With the release of FlyBase 2.0, there has also been a restructuring of backend architecture and a continued development of application programming interfaces (APIs) for programmatic access to FlyBase data. In this review, we describe these major new features and functionalities of the FlyBase 2.0 site and how they support the use of Drosophila as a model organism for biological discovery and translational research.
Subfields: Insect Science, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c0ee4563e93f63328c340b8394f2bcf8114e3870
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In Molecular Biology
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Citations in the corpus
- OrthoDB v11: annotation of orthologs in the widest sampling of organismal diversity (2022, background): “Users can also navigate to OrthoDB records by following links from FlyBase’s ‘Orthologs’ section, UniProt’s ‘Phylogenomic databases’ section, or NCBI’s ‘Additional links/ Gene LinkOut’ section.”
- RNAcentral 2021: secondary structure integration, improved sequence search and new member databases (2020, background): “FlyBase (37) ncRNA annotations have been continuously updated within RNAcentral.”
- FlyBase: updates to the Drosophila melanogaster knowledge base (2020, background): “In this paper, we highlight a variety of new features and improvements that have been integrated into FlyBase since our last review (3).”