Inaugural Article: A human B cell methylome at 100-base pair resolution

By Tibor A. Rauch, Xiwei Wu, Xueyan Zhong, A. Riggs, G. Pfeifer. 2009

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CpG islands and the regulation of transcription. (2011, positive): “About 17% of orphan CGIs have been found so far in a methylated state, compared with ;3% of CGIs at annotated gene promoters (Illingworth et al. 2008, 2010; Rauch et al. 2009; Maunakea et al. 2010).”
Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility (2012, background): “Moreover, previous findings using whole genome methylation sequencing of PBMC [33] and B cells [32] support our finding that CpG sites in regions of high density such as CpG island and 59UTR were more often unmethylated, while CpG sites located in introns, 39 UTRs and repetitive elements were methyl”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “The majority of all methylated CGIs are associated with genes (68%), and only 32% of all methylated CGIs are intergenic.(96) A positive correlation between intragenic methylation and transcription was detected in human B cells.”
CpG islands – ‘A rough guide’ (2009, background): “PAX6, OSR1 and various members of the Homeobox (HOX) super family have been shown to exhibit cell type-specific DNA methylation at CGIs [29,63,69,79].”