Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity.

By J. Symons, A. Alcamí, Geoffrey L. Smith. 1995

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1. R. Randall
2. A. Takaoka
3. H. Yanai
4. S. Goodbourn
5. M. Gale
6. Zachary D. Smith
7. O. Haller
8. Alexander Meissner

Citations in the corpus

• Interferon signalling network in innate defence (2006, background): “Although the role of this type I IFN-binding protein in natural infection remains to be clarified, it was found to be expressed by other orthopoxviruses such as the cowpox, ectromelia and camelpox viruses (Colamonici et al., 1995; Symons et al., 1995).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “Similarly, VACV and most other orthopoxviruses also encode soluble IFN-a/b-binding proteins (Colamonici et al., 1995; Symons et al., 1995).”
• Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA (2010, background): “Media supplementation with a recombinant version of B18R protein, a Vaccinia virus decoy receptor for type I interferons (Symons et al., 1995), further increased cell viability of RNA transfection in some cell types (data not shown).”
• Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. (2000, background): “Vaccinia virus and most other orthopoxviruses also encode soluble IFNα\β receptor homologues (Symons et al., 1995 ; Colamonici et al., 1995).”
• Viruses and interferon: a fight for supremacy (2002, background): “The vaccinia-virus B18R open reading frame also encodes a soluble IFN-α/β receptor that blocks the binding of IFN-α/β to cell-surface receptor”
• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “They can afford to express soluble IFN-binding proteins which compete with the cellular receptor for its IFN ligand (Alcami et al., 2000; Symons et al., 1995).”