Natural History of Asymptomatic Left Ventricular Systolic Dysfunction in the Community

By Thomas J. Wang, Jane C. Evans, Emelia J. Benjamin, Daniel Levy, E. Leroy, Ramachandran S. Vasan. Circulation, 2003

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Cardiac autophagy is a maladaptive response to hemodynamic stress. (2007, result): “In support of this notion, data from the Framingham Heart Study demonstrate that modest differences in systolic ventricular function are prognostically significant over the long run (41).”
Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. (2005, background): “associated with high mortality.(19) It is important when diagnosed and treatment is available, and the condition is therefore included in these Guidelines.”
Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab (2012, background): “9 risk in mortality compared with participants with LVEF >50%.(25) Accordingly, the American Heart Association/American College of Cardiology guidelines recommend the use of cardioprotective drugs in asymptomatic patients with abnormal LVEF.”