The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
By N. Seidah, S. Benjannet, L. Wickham, J. Marcinkiewicz, Stéphanie Bélanger Jasmin, S. Stifani, A. Basak, A. Prat, M. Chrétien. Proceedings of the National Academy of Sciences of the United States of America, 2003
1,206 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c08bdb936a9e7e658a4468bbb9405a9d954842eb
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Molecular Biology
- Lisa N. Kinch
- Nick V. Grishin
- Robert Langer
- Daniel G. Anderson
- Helen H. Hobbs
- Jonathan C. Cohen
- M. Manoharan
- Jay D. Horton
Citations in the corpus
- PCSK9: a convertase that coordinates LDL catabolism Published, JLR Papers in Press, November 19, 2008. (2009, background): “The N-terminal prodomain remains tightly associated with the 63 kDa mature protein and acts as a chaperone to transport PCSK9 through the secretory pathway (4).”
- Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. (2006, background): “1A).(7) Like other proprotein convertases, PCSK9 undergoes autocatalytic cleavage in the endoplasmic reticulum (ER) at residue 152, between the prodomain and the catalytic domain.”
- Molecular biology of PCSK9: its role in LDL metabolism. (2007, background): “Like other familymembers, the signal sequence (amino acids 1–30) in PCSK9 is followed by the prodomain (amino acids 31–152) and catalytic domain [1] (Figure 1).”
- Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 (2005, background): “Missense mutations in PCSK9 , encoding a serine protease in the secretory pathwa”
- Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates (2008, methodology): “P convertase subtilisin/kexin type 9 (PCSK9) is a member of the mammalian serine proprotein convertase family that typically functions in the proteolytic processing and maturation of secretory proteins (1, 2).”