PCSK9: a convertase that coordinates LDL catabolism Published, JLR Papers in Press, November 19, 2008.
By Jay D. Horton, Jonathan C. Cohen, Helen H. Hobbs. Journal of Lipid Research, 2009
613 citations recorded by the source corpus.
The identification and characterization of proprotein convertase subtilisin-like/kexin type 9 (PCSK9) have provided new insights into LDL metabolism and the causal role of LDL in coronary heart disease (CHD). PCSK9 is a secreted protease that mediates degradation of the LDL receptor by interacting with the extracellular domain and targeting the receptor for degradation. Individuals with loss-of-function mutations in PCSK9 have reduced plasma levels of LDL cholesterol and are protected from CHD; these observations have validated PCSK9 as a therapeutic target and suggested new approaches for the treatment and prevention of CHD.
Subfields: Materials Chemistry, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/96988a891a3a6950f23358310822740825108cbb
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Citations in the corpus
- Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review (2012, background): “Liver LDLR levels and its capacity to clear blood LDL are down-regulated by proprotein convertase Frontiers in Pharmacology | Ethnopharmacology March 2012 | Volume 3 | Article 24 | 4 subtilisin/kexin-type 9 (PCSK9), a plasma protein secreted by this organ (Horton et al., 2009).”
- A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins (2015, neutral): “Themutations occur in a gene that encodes an enzyme called PCSK9, which stands for proprotein convertase subtilisin/kexin type 9 (Horton et al., 2009).”
- How to improve R&D productivity: the pharmaceutical industry's grand challenge (2010, background): “Circulating PCSK9 downregulates hepatic LDL receptors and thus increases serum LDL–cholesterol level”