Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente

By A. García‐Sastre, C. Biron. Science, 2006

946 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/c00a0b81f502a40cf087018779d820cc7b566cae

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In Immunology

In Infectious Diseases

Citations in the corpus

Interferons at age 50: past, current and future impact on biomedicine (2007, background): “cgi?id=148000">Kaposi's sarcoma -associated virus (KSHV) encode proteins that interfere with IRF activation or induction and actions of IFN”
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “Specifically, virus-encoded IFN antagonists inhibit host innate antiviral responses by targeting IFN gene expression or IFN-induced host effector molecules (Garcia-Sastre and Biron, 2006; Haller et al., 2006).”
Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame (ORF) 3b, ORF 6, and Nucleocapsid Proteins Function as Interferon Antagonists (2006, background): “Activation of these genes enables the cell to combat the virus infection and can prevent viral replication (8).”
Antiviral immunity directed by small RNAs. (2007, neutral): “These responses are modulated by host proteins, such as PACT and Tar-binding protein (TRBP; Gupta et al., 2003; Garcia-Sastre and Biron, 2006).”
Type I interferons in host defense. (2006, neutral): “, 2006; Banchereau and Pascual, 2006) and other papers (Honda et al., 2005b; Garcia-Sastre and Biron, 2006; Levy et al., 2003; Stark et al., 1998).”
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “Third, type I IFNs induce the expression of a variety of genes with antiviral function”
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum (2008, background): “Both SARSCoV and MHV [72–74] were found to counteract the induction of interferon via cytoplasmic pattern recognition receptors that can sense the presence of viral dsRNA [9,10] and possibly also viral negative-strand RNAs carrying uncapped 59-triphosphates [75].”