Neuroscience: Glia — more than just brain glue

By N. J. Allen, B. Barres. Nature, 2009

888 citations recorded by the source corpus.

Subfields: Biochemistry, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/c0094e26b1d40d127d8e5702014b0525ac086f7e

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Citations in the corpus

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014, background): “Together with neurons, glia (astrocytes, oligodendrocytes, and microglia) and vascular cells (endothelial cells and pericytes) are essential for the development and function of the nervous system (Allen and Barres, 2009; Molofsky et al., 2012).”
The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting (2016, background): “On the contrary, glial cells perform a long list of essential functions (Baumann and Pham-Dinh, 2001; Haydon, 2001; Ullian et al., 2001; Doetsch, 2003; Nedergaard et al., 2003; Allen and Barres, 2009; Fields, 2010; Han et al., 2013; Kettenmann and Ransom, 2013; Verkhratsky and Butt, 2013).”
The Human Brain in Numbers: A Linearly Scaled-up Primate Brain (2009, neutral): “Many original articles, reviews and textbooks affi rm that we have 100 billion neurons and 10 times more glial cells (Kandel et al., 2000; Ullian et al., 2001; Doetsch, 2003; Nishiyama et al., 2005; Noctor et al., 2007; Allen and Barres, 2009), usually with no references cited.”
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, positive): “They obtained transcriptome profiles of purified human CNS cell types and discovered two distinct stages of human astrocyte development.”
Astrocyte crosstalk in CNS inflammation (2020, background): “While initially considered as ‘brain glue’, providing a structural scaffold necessary for neuronal function, it is now clear that astrocyteneuron interactions reach far beyond the simplistic idea of structural aid (Allen and Barres, 2009; Liddelow and Barres, 2017).”
Pax6 interacts with Iba1 and shows age-associated alterations in brain of aging mice. (2017, background): “8, 18-30. 8. Cunningham CL., Martinez-Cerdeno V., and Noctor SC. (2013). Microglia regulates the number of neural precursor cells in the developing cerebral cortex. J Neurosci. 33(10), 4216–4233. 9. Davis LK., et al. (2008). Pax6 3’ deletion results in aniridia, autism and mental retardation. Hum. G”