Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

By D. Glass, P. Bialek, J. Ahn, M. Starbuck, M. Patel, Hans Clevers, M. Taketo, Fanxin Long, Andrew P. McMahon, R. Lang and 1 more. Developmental Cell, 2005

1,599 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/bfef357722ff0b20a54252b512fb6c9fcb39f1c3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Fanxin Long
2. D. Ornitz
3. J. Smolen
4. G. Karsenty
5. M. Zaidi
6. R. Hen
7. Andrew P. McMahon
8. D. Lacey

In Oncology

1. J. Smolen
2. Fanxin Long
3. M. Zaidi
4. D. Lacey
5. Georg Schett
6. W. Birchmeier
7. G. Karsenty
8. P. Ducy

Citations in the corpus

• Glucocorticoid-induced osteoporosis: pathophysiology and therapy (2007, background): “When GSK-3β is not active, stabilized β-catenin translocates to the nucleus, where it associates with transcription factors to regulate gene expression [19].”
• Development of the endochondral skeleton. (2013, background): “…produce a similar bone phenotype to Lrp5-deficient mice (i.e., increase in osteoblast number and activity with no obvious effect on osteoclasts) (Glass et al. 2005; Holmen et al. 2005; Kramer et al. 2010), LRP5 could function independently of b-catenin, at an earlier stage within the osteoblast…”
• Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. (2005, background): “…et al., 2003; Mba1laviele et al., 2005; Rawadi et al., 2003), and data obwtained by deleting β-catenin activity in differentiated ositeoblastic cells (Glass et al., 2005). e Differentiation of periosteal cells into chondrocytes a can be observed during normal vertebrate skeleton de- A ivelopment…”
• Skeletal remodeling in health and disease (2007, background): “Finally, in addition to effects on osteoblast maturation, β-catenin, cooperatively with the early B-cell factor EBF2, attenuates osteoprotegerin, thereby enhancing osteoclast formatio”
• Dickkopf-1 is a master regulator of joint remodeling (2007, background): “The impact on local bone resorption is based on the regulation of OPG expression by canonical Wnt signaling, which is illustrated by increased serum levels of OPG upon DKK-1 inhibitio”
• Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an entero-bone endocrine axis (2008, methodology): “…negative nature, these results have to be interpreted cautiously, yet that b-Cat haploinsufficiency can in other cell types lead to phenotypic abnormalities strongly suggests that Lrp5 regulates Tph1 expression and serotonin synthesis independently of b-Cat expression in gut (Glass et al., 2005).”
• Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors (2006, background): “Red and green arrows indicate the requirement for Hh and canonical Wnt signaling, respectively; the blue line represents the negative regulation of osteoclasts by OPG.”
• Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. (2008, neutral): “The genetic ablation of -catenin in mice led to an osteopenic phenotype that appeared to be driven primarily by increased bone resorption (119).”
• Building strong bones: molecular regulation of the osteoblast lineage (2011, background): “Because deletion of β-catenin in mature osteoblasts by independent groups did not produce a similar bone phenotype to LRP5-deficient mice (that is, increase in osteoblast number and activity with no obvious effect on osteoclasts”
• The control of chondrogenesis (2006, background): “…pathway and activation of TCF/Lef transcription factors, functions in a cell autonomous manner to induce osteoblast differentiation and suppress chondrocyte differentiation in early chondroprogenitors [Day et al., 2005; Gaur et al., 2005; Glass et al., 2005; Hill et al., 2005; Hu et al., 2005].”