How neuroinflammation contributes to neurodegeneration

By R. Ransohoff. Science, 2016

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Neuroinflammation Induces Neurodegeneration (2016, background): “Contrary to other cells, once the neurons are damaged or degenerated, they are unable to be repaired or regenerate in the CNS [4].”
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States (2018, background): “…of PD, and each of these age-related alterations increases the vulnerability of neurons to a-synuclein pathology, and mitochondrial and autophagy dysfunction (Olanow et al., 2015; Ransohoff, 2016; Sepe et al., 2016; Jahanshahi and Rothwell, 2017; Menzies et al., 2017; Surmeier et al., 2017a).”
Neuroinflammation as a Common Feature of Neurodegenerative Disorders (2019, background): “…and decrease the phosphorylation of tau in a mouse model of type II diabetes (Wyss-Coray and Mucke, 2002) and to decrease phosphorylated tau and improve motor function in a mouse model of tauopathy (hTauP301L); also, there is a report about improvement in motor function on this (Ransohoff, 2016a).”
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future (2023, background): “Neuroinflammation is chronic inflammation in the CNS, which is attributed to activated microglia and astrocytes to produce numerous pro-inflammatory cytokines.(151) Growing evidence demonstrates that neuroinflammation plays a vital role in the neuropathological changes in AD.”