Biochemical signals and biological responses elicited by the focal adhesion kinase.

By M. Schaller. Biochimica et Biophysica Acta, 2001

611 citations recorded by the source corpus.

The focal adhesion kinase, FAK, is an important component of an integrin-dependent signaling pathway, which functions to transmit signals from the extracellular matrix into the cytoplasm. FAK is an essential gene product, since the fak-/- mouse exhibits embryonic lethality. A number of important biological processes, including cell motility and cell survival, are controlled by integrin-dependent signals and FAK has been implicated in regulating these processes. This review will focus upon recent findings providing insight into the mechanisms by which FAK transmits biochemical signals and elicits biological effects.

Subfields: Cancer Research, Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/beff7f743173b9b4aaa943c746094170061f379e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Timothy Yeatman
2. D. Schlaepfer
3. S. Mitra
4. Daniel A. Hanson

In Immunology

1. Timothy Yeatman
2. P. Chiarugi
3. E. Giannoni

In Immunology and Allergy

1. Timothy Yeatman
2. D. Schlaepfer
3. M. Schaller
4. S. Mitra
5. Daniel A. Hanson
6. P. Chiarugi
7. E. Giannoni

Citations in the corpus

• Anoikis molecular pathways and its role in cancer progression. (2013, background): “Several mechanisms are proposed to account for the link between FAK and MAPK [190].”
• Regulation of matrix metalloproteinase gene expression (2007, neutral): “For a more detailed analysis of the regulation of MMP gene expression by the MAPK/FAK-mediated cell signaling, readers are referred to more comprehensive reviews on this subject (Westermarck and Kahari, 1999; Schaller, 2001; Van den Steen et al., 2002).”
• Focal adhesion kinase: in command and control of cell motility (2005, background): “Whereas it was first hypothesized that FAK might bind directly to the cytoplasmic tails of integrin”
• The role of focal-adhesion kinase in cancer — a new therapeutic opportunity (2005, background): “In this regard, the kinase activity of FAK could also influence focal-adhesion turnover by tyrosine phosphorylation of other focal-adhesion substrates, such as CRK-associated substrate (CAS, also known as p130cas) and paxilli”
• MAP kinases and cell migration (2004, background): “FAK FAK is a non-receptor protein tyrosine kinase that localizes at focal adhesions or focal contacts (Schaller, 2001b).”
• A renaissance for SRC (2004, background): “FAK was one of the first identified c-SRC substrates and is thought to regulate growth-factor- and integrin-mediated cellular motility, adhesion and invasion, as well as cell proliferation and surviva”