Sensing and alarm function of resident memory CD8+ T cells

By J. Schenkel, Kathryn A. Fraser, V. Vezys, D. Masopust. Nature Immunology, 2013

625 citations recorded by the source corpus.

CD8+ T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8+ T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previously encountered antigens that precipitate innate-like alarm signals and draw circulating memory CD8+ T cells into the tissue. When memory CD8+ T cells residing in the female mouse reproductive tract encountered cognate antigen, they expressed interferon-γ (IFN-γ), potentiated robust local expression of inflammatory chemokines and induced rapid recruitment of circulating memory CD8+ T cells. Anamnestic responses in front-line tissues are thus an integrated collaboration between front-line and circulating populations of memory CD8+ T cells, and vaccines should establish both populations to maximize rapid responses.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/bed55732254ab369e95bd05d9fb6d859a52e6fe0

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Citations in the corpus

Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites (2017, background): “In mice, CD69 is expressed by the majority of CD4 and CD8 TRMs in multiple sites (Jiang et al., 2012; Masopust et al., 2006; Schenkel et al., 2013; Teijaro et al., 2011), while CD103 is only expressed by certain subsets of CD8 TRM (Bergsbaken and Bevan, 2015; Mueller and Mackay, 2016) and not signif”
Quantifying memory CD8 T cells reveals regionalization of immunosurveillance (2015, methodology): “The next day, mice were challenged transcervically with gp33 peptide to reactivate P14 TRM in the FRT and precipitate an inflammatory response that recruits circulating memory T cells (Schenkel et al., 2013).”
Tissue-Resident Memory T Cells (2014, background): “…(Gebhardt et al., 2009;Masopust et al., 2010), lymphatic canulation (Mackay et al., 1990), transfers of labeled T cells (Hofmann and Pircher, 2011; Masopust et al., 2004; 2010), and/or parabiotic surgery (Iijima and Iwasaki, 2014; Jiang et al., 2012; Klonowski et al., 2004; Schenkel et al., 2013).”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “This results in robust local production of chemokines, such as CXCL9, which recruits circulating memory CD8+ T cells independent of their antigen specificity (217).”