Blimp1 is a critical determinant of the germ cell lineage in mice

By Y. Ohinata, B. Payer, D. O’Carroll, K. Ancelin, Yukiko Ono, Mitsue Sano, S. Barton, Tetyana V. Obukhanych, Michel C. Nussenzweig, A. Tarakhovsky and 2 more. Nature, 2005

1,074 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bed4bb4473b12772d896bbdcfc0dead84b40cbb7

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In Molecular Biology

1. Katsuhiko Hayashi
2. J. Hanna
3. B. Knowles
4. S. Kaech
5. Jonathan L. Tilly
6. M. Matzuk
7. D. Messerschmidt
8. N. Irie

Citations in the corpus

• The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. (2011, background): “BLIMP1, a more downstream transcription factor that represses c-myc and inhibits further proliferation but stimulates the differentiation of progenitor cells,(113) is essential for lineage determination of sebaceous gland stem cells.(114,115) Disturbance of sebaceous gland homeostasis due to loss of”
• Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. (2008, background): “Similarly, Dicer null ESCs can be maintained without LIF,butthey areimpaired intheirability toundergodifferentiation (Kanellopoulou et al., 2005; Murchison et al., 2005 ).”
• The biology of infertility: research advances and clinical challenges (2008, background): “For example, soon after implantation in the mouse embryo, a bone morphogenetic protein (BMP) pathway induces the proliferation and specification of PGC precursors from which PR domain–containing 1 with ZNF domain (PRDM1; also known as BLIMP1) becomes the first exclusive marker of the PGC lineag”
• Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. (2011, positive): “Blimp1 (Prdm1) and Prdm14 are critical transcriptional regulators for the PGC fate (Kurimoto et al., 2008; Ohinata et al., 2005; Vincent et al., 2005; Yamaji et al., 2008).”
• DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “Thus, PGCs at this point display the transcription profiles, chromatin modifications, and DNA methylation levels and patterns characteristic of their somatic origin (Ohinata et al. 2005; Maatouk et al. 2006; Hajkova et al. 2010; Popp et al. 2010; Seisenberger et al. 2012).”
• SOX17 is a Critical Specifier of Human Primordial Germ Cell Fate (2014, background): “The genetic basis of mammalian PGC specification was first established in mice (Saitou et al., 2002; Ohinata et al., 2005; Hayashi et al., 2007), which are specified from postimplantation epiblast cells on embryonic day (E)6.25 in response to bonemorphogenetic protein 4 (BMP4) (Lawson et al., 1999).”
• Blimp-1 promotes terminal differentiation of virus-specific CD8 T cells and represses the acquisition of central memory T cell properties (2009, background): “…Blimp-1, a transcriptional repressor known to regulate the terminal differentiation of diverse cell types, plays a functional role in regulating effector and memory CD8+ T cellfate decisions (Horsley et al., 2006; Magnusdottir et al., 2007; Ohinata et al., 2005; Shapiro-Shelef et al., 2003).”
• Oocyte formation by mitotically-active germ cells purified from ovaries of reproductive age women (2012, background): “2c,d ), as well as matched gene expression profiles rich in markers for early germ cell”
• Production of offspring from a germline stem cell line derived from neonatal ovaries (2009, neutral): “dtd" [ ]> The idea that females of most mammalian species have lost the capacity for oocyte production at birt”