Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses

By Katherine B. Chiappinelli, P. Strissel, A. Desrichard, Huili Li, C. Henke, Benjamin Akman, A. Hein, N. Rote, Leslie M. Cope, A. Snyder and 8 more. 2016

684 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bebbcd086ea15bf5f6e987b804b8c97473f92902

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Guido Kroemer
2. L. Galluzzi
3. L. Zitvogel
4. Oliver Kepp
5. A. Buqué
6. K. Flaherty
7. D. Barbie
8. Russell W. Jenkins

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Oliver Kepp
4. L. Zitvogel
5. A. Bader
6. C. S. Sullivan
7. Douglas R. Green
8. Beth Levine

Citations in the corpus

• Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. (2015, background): “At least in ovarian cancer cells, the administration of decitabine triggers a type I IFN response that involves the reexpression of endogenous retroviruses and the consequent accumulation of viral RNA species in the cytoplasm (Chiappinelli et al., 2015).”
• Mechanisms of resistance to immune checkpoint inhibitors (2018, background): “…cytidine) can induce innate immune responses (Roulois et al, 2015), influence T-cell priming and effector function, modulate immune suppressive cells within the TME (Kim et al, 2014), and enhance response to ICI through induction of endogenous retroviral elements (ERVs) (Chiappinelli et al, 2015).”
• Breast Cancer Immunotherapy: Facts and Hopes (2017, background): “Studies have shown that epigenetic modulation can promote a type I IFN response and restore production of Th type 1 cytokines and chemokines (68, 69).”
• DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity (2020, background): “Accumulating evidence indicates that during cellular stress conditions, endogenous RNA transcripts can be sensed by host PRRs and trigger inflammation (Tarallo et al. 2012; Boelens et al. 2014; White et al. 2014; Chiappinelli et al. 2015; Liddicoat et al. 2015; Roulois et al. 2015; Nabet et al. 2017”
• Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors (2016, background): “Interestingly, recent research results suggest that this non-specific mechanism might play a role in promoting effective anti-tumor immune responses [39, 40].”