TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?

By Michèle T. Martin, J. Lefaix, S. Delanian. International Journal of Radiation Oncology, Biology, Physics, 2000

673 citations recorded by the source corpus.

Subfields: Oncology, Radiology, Nuclear Medicine and Imaging, Surgery

View Paper: https://www.semanticscholar.org/paper/be78921709abfe5f9ced973e51dd6466cfbd522f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. D. Schaue
2. E. L. Kachikwu
3. W. McBride
4. Bostjan Seruga
5. S. Werner
6. L. J. Bernstein
7. Haibo Zhang
8. R. Grose

In Radiology, Nuclear Medicine and Imaging

1. E. L. Kachikwu
2. W. McBride
3. D. Schaue
4. F. Stewart
5. S. Werner
6. R. Grose
7. I. Tannock

In Surgery

1. E. L. Kachikwu
2. W. McBride
3. D. Schaue

Citations in the corpus

• Regulation of wound healing by growth factors and cytokines. (2003, background): “Radiation-induced fibrosis shows several similarities to the fibrosis that results after repair of cutaneous wounds in the adult; there is an extensive infiltration of inflammatory cells, dermal fibroblasts misexpress -smooth muscle actin, fibrous extracellular matrix is aberrantly deposited, and TG”
• Strategies to improve radiotherapy with targeted drugs (2011, background): “and the inhibition of ionizing radiation-induced activation of TGF”
• The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. (2004, background): “In this case, the RIF process is characterised by persistent cellular activation whose retroregulation is overwhelmed, because a chronic activation connected with permanent cyokines production [96,101].”
• TGF-beta and fibrosis in different organs - molecular pathway imprints. (2009, background): “decrease slowly after irradiation in both pig and human skin [120,121].”
• Cytokines and their relationship to the symptoms and outcome of cancer (2008, background): “TGFβ has a crucial role in the initiation, development and persistence of radiation-induced fibrosi”
• Cytokines in Radiobiological Responses: A Review (2012, positive): “Again, TGF-b stimulates fibroblast production of collagen in dermal layers (178, 179).”
• Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. (2006, background): “Liposomal superoxide dismutase may down-regulate TGF-b secretions by myofibroblasts, functioning as an antioxidant and anti-inflammatory agent.(45) Early animal studies show that superoxide dismutase may have an immediate radioprotective effect if given before radiation, possibly changing genetic pr”