Chronic epilepsy and cognition.

By Christian Erich Elger, C. Helmstaedter, M. Kurthen. Lancet Neurology, 2004

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The Developmental Stage of Dentate Granule Cells Dictates Their Contribution to Seizure-Induced Plasticity (2010, background): “Medial temporal lobe epilepsy (mTLE) is often associated with pharmacoresistant seizures and comorbidities of cognitive dysfunction and depression (Mendez et al., 1986; Helmstaedter et al., 2003; Elger et al., 2004).”
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling (2007, background): “The mechanisms that regulate the progression from single seizures toward epilepsy are still unclear, and why epilepsy is commonly associated with cognitive impairment remains poorly understood (Dalby and Mody, 2001; Elger et al., 2004; Magloczky and Freund, 2005).”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “Simplified, two features reflecting human pathology are associated with the KA rodent model of human TLE: epileptogenesis (the occurrence of spontaneous seizures after a latent period) and cognitive impairment (Helmstaedter et al., 2003).”