Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

By J. Malhotra, H. Miao, Kezhong Zhang, Anna Wolfson, S. Pennathur, S. Pipe, R. Kaufman. Proceedings of the National Academy of Sciences of the United States of America, 2008

679 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Surgery

View Paper: https://www.semanticscholar.org/paper/12fec57024532919b1e0059266680c9977b29e8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Shiyu Wang
2. H. Chae
3. Hyung-Ryong Kim
4. Feras Hatahet
5. R. Kaufman
6. H. Malhi
7. Hafiz Muhammad Ali Zeeshan
8. Geum-Hwa Lee

In Epidemiology

1. H. Chae
2. Hyung-Ryong Kim
3. Shiyu Wang
4. R. Kaufman
5. J. Malhotra

In Surgery

1. Shiyu Wang
2. R. Kaufman

Citations in the corpus

• The impact of the unfolded protein response on human disease (2012, background): “The cytotoxic effects of CHOP are at least in part through GADD34 because CHOP and GADD34 knockout animals are protected from ER stress–induced tissue damage (Marciniak et al., 2004; Malhotra et al., 2008; Song et al., 2008).”
• Endoplasmic Reticulum Stress and Associated ROS (2016, background): “Oxidative stress can also be generated by aggregation of factor VIII (a protein that is deficient in the ER in hemophilia A) [47].”
• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, neutral): “It is also noteworthy that treatment of mice with BHA alleviates ER stress [173] but it is not known if the protective effects of BHA are dependent on Nrf2.”
• Endoplasmic Reticulum Stress in Liver Disease (2010, background): “On the other hand, even over expressed wild type VIII led to oxidative stress in the liver with associated protein misfolding, UPR activation, and apoptosis [89].”
• Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation (2009, background): “Second, in a landmark study by Malhotra and co-workers (197), it was shown that the overproduction of a protein containing eight disulfide bonds did not result in oxidative stress in cell culture or in mice, whereas the overproduction of a protein that misfolded in the ER did result in oxidative str”