Endoplasmic Reticulum Stress and Associated ROS

By Hafiz Muhammad Ali Zeeshan, Geum-Hwa Lee, Hyung-Ryong Kim, H. Chae. International Journal of Molecular Sciences, 2016

852 citations recorded by the source corpus.

The endoplasmic reticulum (ER) is a fascinating network of tubules through which secretory and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins, after which they are directed either toward other organelles or to degradation, respectively. The ER redox environment dictates the fate of entering proteins, and the level of redox signaling mediators modulates the level of reactive oxygen species (ROS). Accumulating evidence suggests the interrelation of ER stress and ROS with redox signaling mediators such as protein disulfide isomerase (PDI)-endoplasmic reticulum oxidoreductin (ERO)-1, glutathione (GSH)/glutathione disuphide (GSSG), NADPH oxidase 4 (Nox4), NADPH-P450 reductase (NPR), and calcium. Here, we reviewed persistent ER stress and protein misfolding-initiated ROS cascades and their significant roles in the pathogenesis of multiple human disorders, including neurodegenerative diseases, diabetes mellitus, atherosclerosis, inflammation, ischemia, and kidney and liver diseases.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/381c6e4d8ef1f546f1b0f006915cf40092217b3f

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Citations in the corpus

• Antioxidant response mechanism of freshwater microalgae species to reactive oxygen species production: a mini review (2020, background): “The endoplasmatic reticulum is an organelle present in freshwater microalgae cell, which is responsible for the synthesis of protein and lipid [32,33].”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “Moreover, GSH was proposed as a potential protection mechanism from ER-associated ROS damage [72].”
• Diabetic vascular diseases: molecular mechanisms and therapeutic strategies (2023, background): “Hyperglycemia stimulates inflammatory signals and adaptive signals, accelerating ER stress and mitochondrial dysfunction.(105) In addition, glutamate is a key excitatory neurotransmitter in the central nervous system.”