Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye.

By N. Krinsky, J. Landrum, R. Bone. Annual review of nutrition, 2003

834 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/be267647c25b1733225695ababfaa20d5fa9b48b

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Citations in the corpus

Bioactivity and protective effects of natural carotenoids. (2005, background): “Molecules protecting occular tissue against photooxidative damage may act in two ways: first as filters for damaging blue light, and second as antioxidants quenching excited triplet states or singlet molecular oxygen and scavenge secondary ROS like lipid hydroperoxides or the superoxide radical anio”
Critical review: vegetables and fruit in the prevention of chronic diseases (2012, background): “These carotenoids selectively accumulate in the macula lutea (point of highresolution vision) and protect the pigment epithelial cells from blue light and damage by short-wave rays [234].”
Travel advice on the road to carotenoids in plants. (2010, background): “They constitute the major carotenoids of the yellow pot in the human retina [15] and they protect against age-related acular degeneration, the main cause of blindness in elderly people n the industrialized world [16,17].”
Carotenoids: biochemistry, pharmacology and treatment (2016, background): “Zeaxanthin and lutein act as antioxidants protecting photoreceptor cells from the potential damage caused by free radicals (Krinsky et al., 2003).”
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “The carotenoid pigments lutein, meso-zeaxanthin, and zeaxanthin present in the eye’s retina absorb nearly 90% of blue light, protecting the eye from light-induced oxidative damage (Krinsky et al. 2003).”
A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. (2018, background): “Mode of action Besides specific cases such as that of macular pigments, which filter (or absorb) blue light and thus physically protect the underlying photoreceptor cell layer from light damage [330], common biological mechanisms of action may underlie the proposed health benefits of carotenoids.”
Influence of culture conditions on the productivity and lutein content of the new strain Scenedesmus almeriensis (2008, background): “Thus, there is interest in the development of processes that allows the industrial production of microalgae rich enough in lutein as to supply the daily-recommended uptake of lutein of 6 mg per day [13].”
Outdoor cultivation of microalgae for carotenoid production: current state and perspectives (2007, background): “Not only the development of cataracts and macular degeneration seems to be hampered by lutein (Granado et al. 2003; Krinsky et al. 2003; Olmedilla et al. 2003; Koh et al. 2004) but also the progression of early atherosclerosis (Dwyer et al. 2001).”
Antioxidants and Prevention of Chronic Disease (2004, background): “112 Lutein and zeaxanthin are naturally present in the macula and are found in decreased quantities in the macula of AMD patients.”