The role of selectins in inflammation and disease.

By Klaus Ley. Trends in Molecular Medicine, 2003

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The blood-brain barrier in Alzheimer's disease (2017, neutral): “In the Arc/SweA β mouse model of AD, changes in AQP4 expression emerge just after the appearance of the ﬁ rst A β plaques (Yang et al., 2011).”
Platelet-neutrophil-interactions: linking hemostasis and inflammation. (2007, background): “Selectins interact with cell-surface glycoconjugates and mediate tethering, rolling and adhesion of several types of cells.(39,40) L-selectin is expressed on leukocytes, P-selectin is present on platelets and activated endothelial cells and E-selectin is present on activated endothelial cells.”
Sialic acids in human health and disease (2008, neutral): “These selectin-mediated interactions are dependent on additional modifications of the glycans, such as fucosylation and sulfation, and mediate processes involved in inflammation, lymphocyte recirculation, blood coagulation and reperfusion injury [96,97].”
Glycans in cancer and inflammation — potential for therapeutics and diagnostics (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6402">L-selectin ) mediate the transient initial interaction that results in rolling of the leukocytes along the endothelial surfac”
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. (2019, background): “Selectins are membrane-bound glycoproteins consisting of three members: E- (endothelial), P- (platelet), and L- (leukocyte) selectins (116).”