Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
By S. Aller, Jodie Yu, A. Ward, Yue Weng, S. Chittaboina, R. Zhuo, P. Harrell, Yenphuong T. Trinh, Qinghai Zhang, I. Urbatsch and 1 more. Science, 2009
1,962 citations recorded by the source corpus.
Subfields: Infectious Diseases, Oncology
View Paper: https://www.semanticscholar.org/paper/bcb3afea1e45974daeb2358f5b57207d59c37d79
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In Oncology
- Simone Brabletz
- Thomas Brabletz
- Jie Zheng
- Harald Schuhwerk
- Marc P. Stemmler
- C. Klaassen
- Lauren M. Aleksunes
- M. Trudeau
Citations in the corpus
- A Novel Chemometric Method for the Prediction of Human Oral Bioavailability (2012, result): “of OB values, in agreement with these reported models [8,9,11,12].”
- Protein Modelling: What Happened to the “Protein Structure Gap”? (2013, neutral): “Prominent examples include pharmacologically highly relevant drug targets such as GPCRs (Kobilka and Schertler, 2008), drug efflux transporters (Aller et al., 2009; Nakashima et al., 2013), or ion channels (Gouaux and Mackinnon, 2005).”
- Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections (2010, background): “At present, based on physicochemical properties, it is difficult to predict whether a drug is a strong ligand of P-gp or not (6).”
- Computational Methods in Drug Discovery (2014, background): “, 2005), and drug transporters such as Pglycoprotein (Aller et al., 2009) have been determined.”
- Handbook of ion channels (2015, background): “The crystal structures of ABC exporters obtained under a nucleotide-free condition showed an outward-facing MSD with separated NBDs, for example (Locher et al., 2002; Aller et al., 2009; Hohl et al., 2012); in contrast, the crystal structure obtained with a nucleotide showed an inward-facing MSD but”