Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

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Handbook of ion channels (2015, background): “In the activated state structure of a voltagegated potassium channel, the first four charges are in a wateraccessible external crevice and the remaining charges are in an internal facing crevice separated by a highly conserved phenylalanine (58).”
hERG K(+) channels: structure, function, and clinical significance. (2012, background): “Subsequently, these models of the pore have been validated by crystal structures of multiple K channel proteins (111, 150, 244, 297, 337, 384, 386, 619, 682), as well as a bacterial voltage-gated Na channel (479).”
Voltage‐gated sodium channels at 60: structure, function and pathophysiology (2012, background): “3C, warmer colors), similar to voltage-gated potassium channels (Long et al. 2007).”
Patterns of coevolving amino acids unveil structural and dynamical domains (2017, methodology): “For deﬁniteness, we focus on three different 6TM families: the voltage-gated potassium-selective channel [Kv, PDB ID 2R9R (71 we used is the most comprehensive available at the moment, its size is clearly limited by comparison with the much better populated cases discussed previously, showing a…”