The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
By Jiangbin Ye, M. Kumanova, Lori S. Hart, K. Sloane, Haiyan Zhang, D. D. De Panis, E. Bobrovnikova-Marjon, J. Diehl, D. Ron, C. Koumenis. EMBO Journal, 2010
678 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bc390a5c5c817d4e591f633e3f87b23f3433b111
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In Cell Biology
- R. Kaufman
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- Afshin Samali
- A. Gorman
- Peter Walter
- Han Li
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- Mauro Costa-Mattioli
In Molecular Biology
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Citations in the corpus
- Pharmacological brake-release of mRNA translation enhances cognitive memory (2013, background): “During tumor growth, hypoxic conditions and a lack of nutrients can activate both PERK and GCN2, and PERK−/− or GCN2−/− MEFs give rise to significantly smaller tumors in mouse xenograft models than their wild-type counterparts (Bi et al., 2005; Ye et al., 2010).”
- The impact of the unfolded protein response on human disease (2012, background): “It is now evident that intracellular signaling, such as insulin anabolic responses, as well as metabolic conditions including hyperlipidemia, hyperhomocysteinemia, hyperglycemia, and inflammatory cytokines all disrupt protein folding in the ER.”
- The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression (2013, background): “RESULTS Amino acid starvation elicits upregulation of a large number of autophagy genes It is well established that autophagy is induced following amino acid starvation in mammalian cells (36,49,50).”
- The integrated stress response (2016, positive): “GCN2 activation has also been reported in response to a prolonged glucose deprivation in tumor cells, although this is probably an indirect effect resulting from the consumption of amino acids as an alternative energy source in the absence of glucose [7].”
- The eIF2α kinases: their structures and functions (2013, positive): “It is also activated by glucose deprivation in both yeast [204], and mammalian cells [206], although the exact mechanism remains to be defined.”
- The integrated stress response: From mechanism to disease (2020, background): “Tumors lacking GCN2 or ATF4 growmore slowly (196, 197).”