Genealogies of mouse inbred strains
By Jon Beck, Sarah Lloyd, M. Hafezparast, Moyha Lennon-Pierce, Janan T. Eppig, M. Festing, E. Fisher. Nature Genetics, 2000
865 citations recorded by the source corpus.
The mouse is a prime organism of choice for modelling human disease. Over 450 inbred strains of mice have been described, providing a wealth of different genotypes and phenotypes for genetic and other studies. As new strains are generated and others become extinct, it is useful to review periodically what strains are available and how they are related to each other, particularly in the light of available DNA polymorphism data from microsatellite and other markers. We describe the origins and relationships of inbred mouse strains, 90 years after the generation of the first inbred strain. Given the large collection of inbred strains available, and that published information on these strains is incomplete, we propose that all genealogical and genetic data on inbred strains be submitted to a common electronic database to ensure this valuable information resource is preserved and used efficiently.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bc06f1ed90d0fd92d0441f96659d44e337f84401
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Citations in the corpus
- T2Rs function as bitter taste receptors. (2000, background): “The presence of only two alleles at this locus is not unexpected because the strains that share the same polymorphisms were derived from a common founder (Beck et al., 2000).”
- Food Intake, Water Intake, and Drinking Spout Side Preference of 28 Mouse Strains (2002, background): “This set includes most of the commonly used strains, as well as representatives of genealogically unrelated strains (Altman and Katz, 1979; Beck et al., 2000), including CAST/ Ei which is a different subspecies of M.”
- Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance (2017, neutral): “All slides were digitally scanned on a Nanozoomer-XR digital slide scanner (Hamamatsu Photonics K. K., Japan) for semiquantitative analysis of invasiveness and inflammation.”
- Automated apparatus for quantitation of social approach behaviors in mice (2004, background): “The three strains were C57BL/6J, from the C57-related mice, DBA/2J, one of Castle’s mice, and FVB/NJ, a Swiss line (Beck et al. 2000), chosen for their different lineages and frequent use in behavioral genetics research.”
- Mouse models of diabetic nephropathy. (2005, background): “over the past century, with each strain genetically being homogeneous and offering a unique array of phenotypes (8,9).”
- Caring for the Multiple and the Multitude: Assembling Animal Welfare and Enabling Ethical Critique (2012, background): “There are over 450 known inbred mouse strains, which have been developed through selective inbreeding in laboratories which are geographically dispersed or use different mouse models to examine specific human diseases (Beck et al, 2000).”
- Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth (2009, background): “These two commonlyused inbred mouse strains are genetically quite distant [21,22], and they have distinct metabolic phenotypes: Compared with FVB mice, C57 mice have low circulating triglyceride levels [21] and increased triglyceride clearance [23,24]; FVB mice are characterized by relatively higher”