Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor

By Fang Li, Wenhui Li, M. Farzan, S. Harrison. Science, 2005

2,023 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bbedaafec1ea70e9ae405d1f2ac4c143951630bc

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Citations in the corpus

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike (2020, methodology): “The RBD has a very similar structure to that seen in the complex of SARS-CoV-2 RBD with ACE2, rmsd for 194 Ca atoms of 0.6 Å2 (PDB, 6M0J (Lan et al., 2020)), and an rmsd of 1.1 Å2 compared to the SARS CoV RBD (PDB, 2AJF (Li et al., 2005)).”
Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1 (2017, background): “The insertion loops of SARS-CoV and MERS-CoV contain the receptor-binding motifs essential for receptor interaction [25] [26] [27] .”
Structure, Function, and Evolution of Coronavirus Spike Proteins (2016, background): “The structure of betacoronavirus SARS-CoV S1-CTD complexed with human ACE2 provided the first atomic view of coronavirus S1 (52, 53) (Figure 3a).”
Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2 (2020, background): “In the S1 subunit, the receptor‐binding domain (RBD), spanning about 200 residues, consists of two subdomains: the core and external subdomains.14,15 The RBD core subdomain is responsible for the formation of S trimer particles.16 The external subdomain contains two exposed loops on the surface, whi”
Structural insights into coronavirus entry (2019, background): “Remarkably, viruses from different genera, such as HCoV-NL63 (α-CoV) and SARS-CoV (β-CoV), can recognize the same region of ACE2 (entry receptor) using structurally distinct B domains (Hofmann et al., 2005; Li et al., 2005a Li et al., , 2003 Wu et al., 2009 ).”
The Molecular Biology of Coronaviruses (2006, methodology): “The basis for the results that were obtained was then deduced from the x-ray structure of human ACE2 in a complex with the SARS-CoV S protein RBD (Li et al., 2005b).”
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor (2020, background): “Chinese horseshoe bats serve as natural reservoir hosts for SARS-CoV (Lau et al., 2005; Li et al., 2005a).”
The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes (2020, neutral): “cross-species infection and person-to-person transmission[9, 25].”
A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS (2020, positive): “The TCID50 was determined by infection of Huh7 cells (Li et al., 2005b).”
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade (2020, background): “The SARS-CoV S1protein contains a conserved Receptor Binding Domain (RBD), which recognises the angiotensin-converting enzyme 2 (ACE2) (Li et al., 2003).”