Intensive versus conventional glucose control in critically ill patients.

By S. Finfer, D. Chittock, Steve Su, D. Blair, D. Foster, V. Dhingra, R. Bellomo, D. A. Cook, P. Dodek, W. Henderson and 11 more. New England Journal of Medicine, 2009

4,398 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/bb374a68091c6abc42b06843b90c2d56496fbc92

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In Endocrinology, Diabetes and Metabolism

In Epidemiology

Citations in the corpus

Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data (2009, methodology): “The Normoglycemia in Intensive Care Evaluation — Survival Using Glucose Algorithm Regulation (NICE-SUGAR) study, an international multicentre trial involving 6104 patients, is the largest trial of intensive insulin therapy to date.(18) It has reported 1580 deaths.”
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, result): “The RCTs studied mixed populations of surgical and medical ICU patients and found that intensive insulin therapy did not significantly decrease mortality, whereas the NICE-SUGAR trial demonstrated an increased mortality [451].”
ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. (2012, neutral): “there is a high risk of hypoglycaemia-related events when using intensive insulin therapy.(204) The definitive answer with regard to”
Long-term complications of critical care (2011, background): “However, in separate studies, it has also been associated with increased rates of hypoglycemia and 90-day mortality (44, 45).”
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) (2009, background): “02).(284) There was concern that severe hypoglycemia in this study might exacerbate deficits in the injured brain.”
An Endocrine Society Clinical Practice Guideline Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient: (2010, background): “In the intensive care unit, glycemic control can be maintained with a nurse-driven, dynamic intensive insulin therapy protocol targeting a blood glucose level of 140– 180 mg/dl (151).”