Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term…

By F. Silverstein, G. Faich, J. Goldstein, L. Simon, T. Pincus, A. Whelton, R. Makuch, G. Eisen, N. Agrawal, W. Stenson and 6 more. Journal of the American Medical Association (JAMA), 2000

3,363 citations recorded by the source corpus.

Subfields: Pharmacology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/bb1ee6c01ff41a445b9416c1749dd230d6b5dacf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pharmacology

1. David Moher
2. Douglas G. Altman
3. K. F. Schulz

In Rheumatology

1. Martina Anzaghe
2. Sebastian Schneeweiss
3. Yen-Ju Lin
4. S. Schülke

Citations in the corpus

• Guidelines for the management of rheumatoid arthritis: 2002 Update. (2002, positive): “Nonsteroidal antiinflammatory drugs (NSAIDs), glucocorticoid joint injection, and/or low-dose prednisone may be considered for control of symptoms.”
• Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004, background): “A supratherapeutic dose of celecoxib (400 mg b.i.d.) was compared with therapeutic doses of ibuprofen (800 mg t.i.d.) and diclofenac (75 mg b.i.d.) in approximately 8000 patients (Silverstein et al., 2000).”
• The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration (2001, background): “Consequently, the results of this study do not address the occurrence of rare adverse events, nor can they be extrapolated to all patients seen in general clinical practice (180).”
• Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics (2006, background): “Physicians who act rationally and follow treatment guidelines will prescribe COX-2selective NSAIDs to patients with a history of GI irritation or hemorrhage;(14) this subgroup of NSAIDs has demonstrated reduced gastric side effects in randomized clinical trials (RCT).(15,16) Because these patients a”
• Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis (2020, background): “long-term application of glucocorticoids is hampered by severe multisystemic metabolic side-effects such as gastrointestinal bleeding, osteoporosis, and ulcer formation [1,2,168].”