Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.

By Patricia M. D’Cruz, D. Yasumura, Jessica Weir, M. Matthes, H. Abderrahim, M. Lavail, D. Vollrath. Human Molecular Genetics, 2000

896 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/bb1b67a45a5f3b4c70e5a43947c2bd4e6996c67f

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In Molecular Biology

1. O. Strauß
2. D. Graham
3. H. Earp
4. A. Keating
5. R. Linger

In Ophthalmology

1. O. Strauß

Citations in the corpus

• Neural remodeling in retinal degeneration. (2003, background): “The prime model of this phenomenon is the RCS rat with a deletion mutation in the mertk receptor tyrosine kinase gene (D’Cruz et al., 2000).”
• The retinal pigment epithelium in visual function. (2005, background): “thus ultimately, to loss of POS phagocytosis receptor function (135).”
• Phagocytosis and clearance of apoptotic cells is mediated by MER (2001, background): “Recently, a rat model with retinal degeneration where failure of retinal pigment epithelial cells to phagocytose the shed outer segment layers results in the death of photoreceptor cells, and human patients with retinitis pigmentosa have been shown to contain mutations in the mer gen”
• TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. (2008, background): “Two groups independently discovered that the genetic basis for RPE dysfunction in the RCS rat was due to a deletion of the second exon of Mer leading to aberrant transcription with a frameshift and translation termination signal 20 codons after the AUG (D’Cruz et al., 2000; Nandrot et al., 2000).”
• Leber congenital amaurosis: genes, proteins and disease mechanisms. (2008, background): “A mutation in the MERTK gene was initially identified in the Royal College of Surgeons (RCS) rat, a classical model of retinal degeneration in which the RPE fails to phagocytose shed outer segments (D’Cruz et al., 2000; Nandrot et al., 2000).”
• A role for Mer tyrosine kinase in αvβ5 integrin-mediated phagocytosis of apoptotic cells (2005, background): “…l o f C el l S ci en ce 540 variation in the Royal College of Surgeons (RCS) rat model result in progressive loss of vision and retinal dystrophy due to impaired clearance of rod outer segments (ROS) by associated retinal pigmented epithelial (RPE) cells (D’Cruz et al., 2000; Peng et al., 2003).”