Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades.

By Boris N. Kholodenko. European Journal of Biochemistry, 2000

705 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bb1b66e7327a2fb1436df251839828fe387fa75b

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Citations in the corpus

Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. (2003, background): “Negative feedback has been proposed as a basis for oscillations in protein synthesis [44], MPF activity [45], MAPK signaling pathways [46], and circadian rhythms [47,48,49"].”
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades (2004, background): “responses, including oscillations, gradual and ultrasensitive responses, and discontinuous bistable switches (Huang and Ferrell, 1996; Kholodenko et al., 1997; Kholodenko, 2000; Bhalla et al., 2002; Heinrich et al., 2002).”
Cancer: a Systems Biology disease. (2006, background): “Feedback loops, in which a component of a pathway positively or negatively regulates the activity of upstream components of the pathway, can dramatically influence the output of a network (Bhalla and Iyengar, 1999; Ferrell, 1999, 2002; Kholodenko, 2000; Asthagiri and Lauffenburger, 2001).”
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. (2005, methodology): “The signalling component of this model consisted of the ODE model developed by Kholodenko et al. (1999) [60], highlighting that ODE based models can be utilised by other modelling”
CellDesigner 3.5: A Versatile Modeling Tool for Biochemical Networks (2008, background): “6 shows a simulation result of a mitogen-activated protein kinase (MAPK) cascades model proposed by Kholodenko [16].”
Cell-signalling dynamics in time and space (2006, background): “A multitude of negative-and positive-feedback loops enable cascades to generate gradual and ultrasensitive responses, multi-stability and oscillations 12,18,20,46,47,72–74 .”
Monotone control systems (2002, background): “This is the model studied in [16], from which we also borrow the”
Rule-Based Modelling of Cellular Signalling (2007, neutral): “We thus expect a cyclic process of activation and then inhibition of Ras, leading to an oscillating activation pattern for ERK, typical of a cascade embedded in a negative feedback loop [16].”