Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon.

By Takanobu Kato, T. Date, M. Miyamoto, A. Furusaka, K. Tokushige, M. Mizokami, T. Wakita. Gastroenterology, 2003

641 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/baac0beef13c4301eb60bb27b2a07d32c33a0902

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Charles M. Rice
2. Brett D. Lindenbach Heinz-J
3. S. Belouzard
4. Peter Simmonds

In Hepatology

1. Charles M. Rice
2. Brett D. Lindenbach Heinz-J
3. S. Belouzard
4. D. Moradpour
5. Peter Simmonds
6. François Penin
7. Ralf Bartenschlager

Citations in the corpus

• Genetic diversity and evolution of hepatitis C virus--15 years on. (2004, background): “The range of HCV variants that can be cultured is extremely restricted (limited to genotypes 1a and 1b), which are both equivalently IFN-resistant clinically, although a full-length replicon of the more clinically sensitive genotype 2a has recently been described (Kato et al., 2003).”
• Production of infectious hepatitis C virus in tissue culture from a cloned viral genome (2005, background): “replicate efficiently in Huh7 cells and do not require cell culture–adaptive mutation”
• Flaviviridae :T he Viruses and Their Replication (2007, background): “A particularly interesting replicon is the genotype 2a JFH-1 isolate, which efficiently replicates in several cell types without adaptive mutations (322).”
• Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis (2006, methodology): “In vitro-transcribed RNA was delivered to Huh-7 cells by electroporation as described previously ( 25 ).”
• EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy (2011, neutral): “Electroporation of RNA derived from plasmid pSGR-JFH1 or replication-deficient mutant pSGR-JFH1/GND (Δ”
• Replication of hepatitis C virus (2007, background): “An unexpected twist came when an HCV genotype 2a clone isolated from a Japanese patient with a rare case of fulminant hepatitis C , designated as JFH-1 (for Japanese fulminant hepatitis 1) was found to replicate in Huh-7 and other cell lines without the requirement for adaptive mutation”