A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

By S. Friso, Sang-Woon Choi, D. Girelli, J. Mason, Gregory Dolnikowski, P. Bagley, O. Olivieri, P. Jacques, I. Rosenberg, R. Corrocher and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

976 citations recorded by the source corpus.

Subfields: Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/baa4289d7897b70d5f5789e8209fa7ad6cbd49fd

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In Molecular Biology

1. Partha M. Das
2. R. Singal
3. Jean-Pierre Issa

Citations in the corpus

• A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. (2004, background): “DNA can be digested into single nucleotides and total genomic 5-methylcytosine can be quantitated by either high-performance liquid chromatography (13,14), thin-layer chromatography (15), or liquid chromatography/mass spectroscopy (16).”
• DNA methylation and cancer. (2004, background): “It was found that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status.(90) Another study examined the relationship between plasma folate status and colorectal adenomas with reference to effect modification by the genetic polymorphism (C677T) of th”