The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting.

By E. Ibrahim, G. Sherman, Suzanne B. Ward, Victoria J. Fraser, Marin Kollef. Chest, 2000

1,857 citations recorded by the source corpus.

Subfields: Applied Microbiology and Biotechnology, Clinical Biochemistry, Critical Care and Intensive Care Medicine

View Paper: https://www.semanticscholar.org/paper/baa4062d58c0b3ce331e133d7ec1a62164e76036

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In Applied Microbiology and Biotechnology

In Clinical Biochemistry

In Critical Care and Intensive Care Medicine

Citations in the corpus

Epidemiology of Invasive Mycoses in North America (2010, background): “Fungal BSIs have been shown to have some of the highest rates of inappropriate therapy and hospital mortality among all etiologic agents examined (Harbarth et al. 2002; Ibrahim et al. 2000; Klevay et al. 2008; Morgan et al 2005a; Morrell et al. 2005; Parkins et al. 2007).”
Bloodstream Infections Caused by Antibiotic-Resistant Gram-Negative Bacilli: Risk Factors for Mortality and Impact of Inappropriate Initial Antimicrobial Therapy on Outcome (2004, background): “Indeed, there is controversy regarding the impact of inappropriate initial antimicrobial therapy on the outcome of critically ill patients in the ICU setting (2, 7, 17, 23, 24).”
Sepsis and septic shock. (2018, background): “62,69 If a specific pathogen is identified, anti microbial therapy should be tailored accordingly.”
Systematic Review and Meta-Analysis of the Efficacy of Appropriate Empiric Antibiotic Therapy for Sepsis (2010, background): “Estimates of the potential benefit of appropriate empirical antibiotic treatment vary widely in the literature between no effect (21, 22, 48, 70, 84, 88) and adjusted odds ratios (ORs) above 6 (39).”
Better Tests, Better Care: Improved Diagnostics for Infectious Diseases (2013, background): “Consequently, approximately 20%-30% of patients with severe sepsis receive inadequate empiric antimicrobial therapy [19] [20] [21] .”
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. (2012, background): “Infections with MDROs can lead to inadequate or delayed antimicrobial therapy, and are associated with poorer patient outcomes [1–4].”
Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. (2006, background): “of inappropriate initial treatment [6].”
Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome. (2003, neutral): “ceptibility results become available [12–14].”
Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis* (2003, background): “ocomial bacteremia that received inadequate antibiotic therapy (32).”
Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America (2009, neutral): “creased morbidity and mortality [172–177].”
Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. (2003, background): “[11] reported that patients who received inappropriate empirical therapy for bloodstream infections in the ICU were at an almost 7-fold higher risk of mortality, compared with patients who received adequate antimicrobial therapy.”
Delaying the Empiric Treatment of Candida Bloodstream Infection until Positive Blood Culture Results Are Obtained: a Potential Risk Factor for Hospital Mortality (2005, background): “antimicrobial treatment has been shown to be an important independent risk factor for mortality among hospitalized patients with serious infections, including bloodstream infections (12, 19).”
Combination Therapy for Treatment of Infections with Gram-Negative Bacteria (2012, background): “Although the need for definitive combination therapy is questionable, delays in initiating appropriate antimicrobial therapy for pseudomonal infections (which often consists of combination therapy) have been associated with higher mortality (27, 117, 123, 124, 157, 165, 166).”