Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein

By D. Cabin, K. Shimazu, D. Murphy, N. Cole, W. Gottschalk, K. L. McIlwain, B. Orrison, Amy Chen, Christopher E. Ellis, R. Paylor and 2 more. Journal of Neuroscience, 2002

890 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/ba9ee6b93852f74f040dbead72bad3050f9471ca

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In Cellular and Molecular Neuroscience

1. S. Przedborski
2. Leonidas Stefanis
3. W. Dauer
4. Wade G. Regehr
5. Raphael Cohn
6. Ianessa Morantte
7. V. Ruta

In Neurology

1. Leonidas Stefanis
2. S. Przedborski
3. W. Dauer
4. Wade G. Regehr
5. Valina L. Dawson
6. T. Dawson

Citations in the corpus

• Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates (2005, background): “-Syn localizes to nerve terminals (Iwai et al., 1995) and has been implicated in synaptic transmission (Abeliovich et al., 2000; Cabin et al., 2002; Liu et al., 2004; Yavich et al., 2004).”
• Helix periodicity, topology, and dynamics of membrane‐associated α‐Synuclein (2005, background): “Evidence that aS controls synaptic strength comes from neuronal cell line and knockout mouse models (Abeliovich et al. 2000; Murphy et al. 2000; Cabin et al. 2002; Schluter et al. 2003) that display impaired synaptic response to repetitive stimuli and alterations in the number of reserve pool vesicl”
• α-Synuclein in Parkinson's disease. (2012, background): “…of cellular systems in which WT a-synuclein is overexpressed have been instrumental in this regard, as they reveal alterations in neurotransmitter release, which are not always consistent across neuronal systems (Abeliovich et al. 2000; Murphy et al. 2000; Cabin et al., 2002; Larsen et al. 2006).”
• Dopamine release in the basal ganglia (2011, background): “Studies of presynaptic functions of α-synuclein in release regulation suggest that this protein may directly limit transmitter release, particularly glutamate (Chandra et al., 2004; Cabin et al., 2002; Nemani et al., 2010).”
• Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine (2004, background): “The -synuclein protein appears important for maintaining the functional integrity of synaptic vesicles (Cabin et al., 2002).”
• Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly (2003, neutral): “…not “Q” or “Pr.” EM analysis did not reveal any obvious differences in the number of docked vesicles (Figure 2F), which are thought to be the morphological correlate of the readily releasable pool (RRP) of quanta (Cabin et al., 2002; Dobrunz and Stevens, 1997; Larkman et al., 1997; Zucker, 1989).”
• Short-term presynaptic plasticity. (2012, background): “The elimination of a-synuclein reduces the size of the pool of nondocked vesicles by 40% and reduces the extent of depression during sustained stimulation by 30% (Cabin et al. 2002).”
• Parkinson's Disease Mechanisms and Models (2003, background): “Although this form of parkinsonism was originally termed autosomal recessive juvenile parkinsonism, the2003) or hippocampal cultures (Cabin et al., 2002) from synuclein null mice.”