Emerging roles for lipids in shaping membrane-protein function

By Rob Phillips, T. Ursell, Paul A. Wiggins, P. Sens. Nature, 2009

969 citations recorded by the source corpus.

Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ef797271797ad788106e3b3725cea715122def7d

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Citations in the corpus

• Cryo-EM analysis of a membrane protein embedded in the liposome (2020, background): “In addition to residing within or on the surface of the membrane, the interplay between MPs and membranes also has a profound impact on cellular life (5).”