Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

By H. Sakuraba, H. Mizukami, N. Yagihashi, R. Wada, C. Hanyu, S. Yagihashi. Diabetologia, 2002

693 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/ba7693fd7194af36c3d9d51eede841d742646f73

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In Cell Biology

1. E. Gilbert
2. Zhuo Fu
3. Dongmin Liu
4. A. K. Cardozo
5. M. Cnop
6. Decio L. Eizirik

In Genetics

1. E. Gilbert
2. Zhuo Fu
3. Dongmin Liu
4. M. Cnop
5. F. Ortis
6. J. Henquin
7. Decio L. Eizirik

In Surgery

1. E. Gilbert
2. Zhuo Fu
3. Dongmin Liu
4. M. Cnop
5. F. Ortis
6. J. Henquin
7. Decio L. Eizirik

Citations in the corpus

• Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes (2012, positive): “Indeed, those individuals with T2D always manifest increased β-cell apoptosis and reduced β-cell mass [286, 287, 404].”
• Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea (2003, result): “patients is similar to that of normal subjects (9, 10, 13, 37).”
• Initiation and execution of lipotoxic ER stress in pancreatic β-cells (2008, background): “…insulin secretion is probably due to both functional pancreatic-β-cell defects and loss of β-cell mass (Butler et al., 2003; Clark et al., 1988; Klöppel et al., 1985; Sakuraba et al., 2002; Yoon et al., 2003) by apoptosis (Butler et al., 2003; Del Guerra et al., 2005; Marchetti et al., 2004).”
• β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes (2003, neutral): “However, more recent reports in which clinical information was better characterized conclude that -cell mass is decreased in type 2 diabetes (9,22,24), whereas others report no decrease in -cell mass (19,21).”
• Pancreatic β‐cell mass in European subjects with type 2 diabetes (2008, background): “More recent studies using immunohistochemical identification of the two cell types have reported that the relative volume density of alpha cells vs beta cells tended to be higher [15, 16] or was significantly higher [3, 4, 6, 17– 19] in type 2 diabetic patients than in non-diabetic subjects.”