The transcription factor Sox10 is a key regulator of peripheral glial development.

By S. Britsch, Derk E. Goerich, D. Riethmacher, R. Peirano, M. Rossner, K. Nave, C. Birchmeier, Michael Wegner. Genes & Development, 2001

911 citations recorded by the source corpus.

The molecular mechanisms that determine glial cell fate in the vertebrate nervous system have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest cells. We show here that the transcription factor Sox10 is a key regulator in differentiation of peripheral glial cells. In mice that carry a spontaneous or a targeted mutation of Sox10, neuronal cells form in dorsal root ganglia, but Schwann cells or satellite cells are not generated. At later developmental stages, this lack of peripheral glial cells results in a severe degeneration of sensory and motor neurons. Moreover, we show that Sox10 controls expression of ErbB3 in neural crest cells. ErbB3 encodes a Neuregulin receptor, and down-regulation of ErbB3 accounts for many changes in development of neural crest cells observed in Sox10 mutant mice. Sox10 also has functions not mediated by ErbB3, for instance in the melanocyte lineage. Phenotypes observed in heterozygous mice that carry a targeted Sox10 null allele reproduce those observed in heterozygous Sox10(Dom) mice. Haploinsufficiency of Sox10 can thus cause pigmentation and megacolon defects, which are also observed in Sox10(Dom)/+ mice and in patients with Waardenburg-Hirschsprung disease caused by heterozygous SOX10 mutations.

Subfields: Cancer Research, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/ba728b584b8dcc4099edcdfc08a2ce14a0e3c4c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Mirsky
2. K. Jessen

In Molecular Biology

1. M. Wegner
2. Marie-Christine Chaboissier
3. C. Stolt
4. A. Schedl
5. E. Sock
6. D. Falls
7. P. Lommes

Citations in the corpus

• Schwann Cells: Development and Role in Nerve Repair. (2015, background): “In crest cells, Sox10 maintains expression of ErbB3 receptors for neuregulin, a growth factor that indirectly promotes gliogenesis from crest cells (Britsch et al. 2001).”
• The origin and development of glial cells in peripheral nerves (2005, background): “Similarly, although the transcription factor SOX10 is required for glial development, it is expressed by all neural crest cells and therefore does not seem to be part of a classical inductive signalling cascade for the activation of glial developmen”
• Neuregulins: functions, forms, and signaling strategies. (2003, background): “[174] S.”
• The Sox9 transcription factor determines glial fate choice in the developing spinal cord. (2003, methodology): “In situ hybridizations were carried out on 20-µm-thick cryotome sections as described (Britsch et al. 2001) using DIG-labeled probes for Nkx6.”