Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress

By K. Esposito, F. Nappo, R. Marfella, G. Giugliano, F. Giugliano, M. Ciotola, L. Quagliaro, Antonio Ceriello, D. Giugliano. Circulation, 2002

1,986 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/ba51938d5cb91dad00eb7512b59b268cb65fc55f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Jaswinder K. Sethi
2. Antonio Ceriello
3. I. Hirsch
4. J. Pickup
5. W. Cawthorn
6. V. Basevi

In Epidemiology

1. J. Sullivan
2. Jaswinder K. Sethi
3. Antonio Ceriello
4. I. Hirsch
5. Christie M. Ballantyne
6. J. Pickup
7. W. Cawthorn
8. A. Elmarakby

Citations in the corpus

• Postprandial hyperglycemia and diabetes complications: is it time to treat? (2005, background): “Studies support the evidence that an acute hyperglycemia during a hyperglycemic clamp (56) or in the postprandial state (57) can increase the production of plasma interleukin-6, tumor necrosis factor- , and interleukin-18.”
• Management of diabetes and hyperglycemia in hospitals. (2004, positive): “In humans, moderate elevation of glucose to 270 mg/dl (15 mmol/l) for 5 h has been associated with increased IL-6, IL-18, and TNF- (62).”
• Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. (2012, background): “In addition, in older diabetic patients with poor glycemic control and asymptomatic individuals with abnormal fasting glycemia, thiobarbituric acid-reactive substances a marker of oxidative stress, and IL-6 levels are independently correlated with C-reactive protein, suggesting that oxidative stress”
• Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. (2003, background): “Also, reverse causality should be considered, as recent studies have shown that hyperglycemia, by producing oxidative stress, is itself proinflammatory (40).”
• The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. (2005, background): “he potential mechanism for this association may be comlex, involving not only stimulation of the HPA axis and the ympathetic nervous system but also potential synergy inuced by peripheral effects, such as hyperglycemia (62).”
• TNF-α and adipocyte biology (2007, background): “Additionally, oxidative stress may promote increased production of TNF-a under adverse metabolic conditions [103].”
• Mechanisms linking obesity with cardiovascular disease (2006, background): “Inflammatory cytokines are also acutely increased by hyperglycaemi”
• Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. (2004, background): “And particularly cogent is the recent finding that acute hyperglycemia in nondiabetic and IGT subjects elevates plasma IL-6 and TNF- concentrations, higher and longer in individuals with IGT and when the glucose was given as pulses (126).”