Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.

By D. Krause, N. Theise, M. Collector, O. Henegariu, Sonya J. Hwang, Rebekah Gardner, Sara Neutzel, S. Sharkis. Cell, 2001

2,781 citations recorded by the source corpus.

Purification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent the gold standard for demonstrating self-renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bone marrow can LTR primary and secondary recipients. During the homing, CD34 and SCA-1 expression increases uniquely on cells that home to marrow. These adult bone marrow cells have tremendous differentiative capacity as they can also differentiate into epithelial cells of the liver, lung, GI tract, and skin. This finding may contribute to clinical treatment of genetic disease or tissue repair.

Subfields: Genetics, Hematology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/b9d9fdd0bfd86a66668dbae3191003d165fc98b2

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In Pulmonary and Respiratory Medicine

Citations in the corpus

Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice1 (2007, background): “The low level of engraftment seen ( 5%) is consistent with prior studies in the field (3, 7), which have reported engraftment levels 1% even in the presence of lung injury.”
Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. (2005, background): “BM cells appear to have the capacity to repopulate many nonhematopoietic tissues, such as neuroectodermal cells (3, 4), skeletal myoblasts (5), CMCs (6, 7), endothelium (6–8), hepatocytes (9), and lung, gut, and skin epithelia (10).”
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? (2002, background): “Haematopoietic stem cells are stored in a bone-marrow microenvironment known as the stem-cell 'niche', where they are maintained in an undifferentiated and quiescent stat”
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, methodology): “After transplantation of bone marrow or enriched hematopoietic stem cells, skeletal lung, gut, and skin epithelia (18), myoblasts (19, 20), cardiac myoblasts (21, 22), endothelium (23, 24), hepatic and biliary duct epithelium (14, 25, 26), or neuroectodermal cells (27, 28) of donor origin can be fou”