Nutrient Sensing Mechanisms and Pathways
By A. Efeyan, William C. Comb, David M. Sabatini. Nature, 2015
1,040 citations recorded by the source corpus.
The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.
Subfields: Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, Surgery
View Paper: https://www.semanticscholar.org/paper/b982bd73ca3b487f35831b40a2f46c40305f48a9
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In Nutrition and Dietetics
In Surgery
Citations in the corpus
- Metabolic Control of Longevity. (2016, background): “Deregulated Nutrient Sensing Different signaling pathways that sense and respond to fluctuations in nutrient levels are commonly deregulated during aging and in the presence of metabolic disorders (Efeyan et al., 2015).”