Interneuron Cell Types: Fit to form and formed to fit

By Adam Kepecs, G. Fishell. Nature, 2014

1,042 citations recorded by the source corpus.

Understanding brain circuits begins with an appreciation of their component parts — the cells. Although GABAergic interneurons are a minority population within the brain, they are crucial for the control of inhibition. Determining the diversity of these interneurons has been a central goal of neurobiologists, but this amazing cell type has so far defied a generalized classification system. Interneuron complexity within the telencephalon could be simplified by viewing them as elaborations of a much more finite group of developmentally specified cardinal classes that become further specialized as they mature. Our perspective emphasizes that the ultimate goal is to dispense with classification criteria and directly define interneuron types by function.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/b95a7c6a24c5a8c0638cc95b66c9c573dd7e4180

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Neurology

Citations in the corpus

Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, background): “…of interneurons in the cortex (Freund and Buzs aki, 1996; Hippocampus McBain and Fisahn, 2001; Solt esz, 2005; Klausberger and Somogyi, 2008; Fishell and Rudy, 2011; Kepecs and Fishell, 2014) and hippocampal interneurons show diverse firing patterns during SPW-Rs from potent increase to silence.”
GABAergic interneurons in the neocortex: From cellular properties to circuits (2016, neutral): “lished in recent years highlighting these new discoveries (Kepecs and Fishell, 2014; Roux and Buzsáki, 2015) (see also articles in Fishell and Tamás, 2014).”
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain (2015, background): “PV and VIP neurons have distinct computational roles as a result of differences in their firing patterns and synaptic connections (Kepecs and Fishell, 2014).”
The origin and evolution of cell types (2016, background): “The starting point was a precursor cell type with two modules (1, 2).”