Signal Transduction by the TGF-β Superfamily

By L. Attisano, Jeffrey L. Wrana. Science, 2002

1,194 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/b94f69c7668a67a31b18f500fda069caec8ab605

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Massagué
2. J. Seoane
3. D. Wotton
4. R. Derynck
5. H. Lan
6. Xiao-ming Meng
7. Søren Bentzen
8. P. Tang

In Pathology and Forensic Medicine

1. J. Massagué
2. J. Seoane
3. D. Wotton
4. Søren Bentzen
5. R. Derynck

Citations in the corpus

• Smad transcription factors. (2005, methodology): “For more information on the biology of the TGF family, we would recommend several classical reviews (Letterio and Roberts 1998; Whitman 1998; Massagué and Chen 2000; Massagué et al. 2000; Derynck et al. 2001; Attisano and Wrana 2002; Schier 2003).”
• The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective (2019, background): “TGFβ regulates transcription by Smad‐dependent and independent TGFβ receptor signaling pathways (Attisano & Wrana, 2002; Long, Zuo, & Park, 2005; Van Grunsven et al., 2007).”
• TGF-β/Smad signaling in renal fibrosis (2015, background): “Additionally, TGF-β1 is able to function through the Smad-independent pathways, including p38, ERK (Extracellular-signal-regulated kinase), MAPK, RhoGTPases, Rac, Cdc42, ILK (Integrin linked kinase) (Attisano and Wrana, 2002; Derynck and Zhang, 2003; Li et al., 2009; Loeffler andWolf, 2014).”
• TGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA (2007, background): “TGF-b proteins are key regulators of development and tissue differentiation (Attisano and Wrana, 2002), and signal through complexes of type II (TbRII) and type I (TbRI) receptors that are characterised as serine-threonine kinases (Chen et al, 1995).”
• TGF-β1-induced Migration of Bone Mesenchymal Stem Cells Couples Bone Resorption and Formation (2009, background): “It is well established that phosphorylation of receptor-regulated SMADs (R-SMADs) by TβRI is the primary TGF-β signaling pathwa”
• Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis (2003, background): “Cooperation between TGF-β receptors and RTKs or other receptors involves many mechanisms (see Ref”
• A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog (2009, methodology): “We have used a phenotypic chemical screen to identify compounds that can replace the reprogramming transcription factor Sox2 and have confirmed the mechanism by which the most potent compound acts: RepSox replaces Sox2 by inhibiting the broadly expressed Tgf-b signaling pathway (Attisano and Wrana, ”
• Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology (2006, background): “The signalling pathway itself is rather simple: the only established intracellular signalling effectors are the Smad proteins, of which there are five R-Smads (receptor-regulated Smads; SMAD1 , 2, 3, 5 and 8) that are directly phosphorylated by the type I receptor, a co-Smad ( SMAD4 ) that forms he”